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TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 226 Ultrastructural Changes in placenta and Immunity Status During Intrauterine Influenza Infection Dodo Sigua Ac. Chachava S/R Institute of Perinatal Medicine, Obstetrics and Gynecology, Tbilisi, Georgia Abstract The state of immunity has been studied in 380 pregnant women and their newborns, having influenza in different stages of pregnancy. The histo- and ultrastructure of 36 afterbirth have been studied. The influenza infection during pregnancy was characterized by serious oppression of all studied immunity indexes both in mothers and in their newborns. In placenta there were found considerable structural changes, also the amount of influenza virus in active state, which is certified not only by the amount of antibodies, but also by ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 The Changes of pH and Partial Pressure of Oxygen in Blood at Chronic Heart Failure Nino Mamamtavrishvili*, Giorgi Red'ko**, Gulnara Tabidze*, Marina Iakobashvili* * Scientific-Research Institute of Cardiology, Tbilisi, Georgia, **TSMU Scientific-Research Institute of Experimental Medicine, Tbilisi, Georgia Abstract Disorders in myocardium metabolism taking place at heart failure are connected with reduced blood supply and promote decrease of ATP production, breaking of oxygen consumption, increase of lactate and hydrogen ions' production. In this connection study of changes of partial pressure of oxygen ions occurring in blood of patients with systolic and diastolic forms of heart failure seems to be of great interest. On the basis of obtained results ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 July/September, Volume 3, Issue 3 The Optimal Scars of Facial Skin Wounds, Operational Technique and Conditions Used for Healing Nino Chuchulashvili Department of Surgical Stomatology, Tbilisi State Medical University, Georgia Abstract We were aimed to achieve cosmetically and functionally acceptable scars after surgical operation in case of facial skin wounds. 36 consecutive patients with facial skin wounds were selected for study. They underwent restorative surgical operation. Wounds were processed by the method elaborated and suggested by us. Among these 36 patients 11 had traumatic cutaneous wounds and 21 had postoperational wounds. Dexasone with the dose of 4 to 8 mg or dexamethasone were administered in wounds. In the process of suturing magnifying glass (binocular lens ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 October/December, Volume 2, Issue 4 356 Interaction of Clinic Roentgenological Characteristics of Dysphasic Coxarthrosis During Endoprosthetics Tornike Nozadze The Orthopedic Clinic "Synthesis", Tbilisi, Georgia Abstract On the basis of clinical and X-ray inspections of 144 patients with dysplastic coxarthrosis (DC) before and after endoprosthetics with application of cluster analysis cause-effect relationship has been established between parameters of DC before and after endoprosthetics, that enables in the presence of scanty diagnostic factors state the diagnosis with high probability. Has been defined a conditioned operational and postoperational complications. Keywords: dysplastic coxarthrosis, endoprosthetics, cluster analysis, X-ray ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Clinical and Immunological Aspects of Treatment of Acute Herpetic Stomatitis with Plaferon-Containing Adhesive Films Nato Korsantia,* Alexander Katsitadze,** Vladimir Bakhutashvili,* Nino Korsantia*** * Institute of Medical Biotechnology of the Georgian Academy of Sciences; ** Department of Dermatology and Venereology, Tbilisi State Medical University, Georgia; *** Department of Pediatric Stomatology, Tbilisi State Medical University, Georgia Abstract The plaferon-containing adhesive films were attached to mucous lesion of patients with acute herpetic stomatitis (plaferon - preparation received from human placenta, which possesses immunomodulating, antihypoxic and desintoxicative effects). Analysis revealed the improvement of clinical indices on ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 240 Effects of Carnitine on 6-Month Incidence of Mortality and Heart Failure in Patients with Acute Myocardial Infarction Bondo Kobulia, Zaza Chapichadze, Givi Andriadze, Pavle Machavariani Scientific-Research Institute of Cardiology, Tbilisi, Georgia Abstract Background: The carnitine therapy for acute myocardial infarction has significant metabolic improvement capacity due to intrinsic mechanisms. We did a trial to compare carnitine with standard therapy in patients with acute myocardial infarction. Material and methods: 98 patients with acute ST-elevation myocardial infarction were randomly assigned to carnitine (n=45) and control (n=53) group. The primary endpoint was 30-day mortality and re-infarction during 96 h of hospitalization. ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 October/December, Volume 2, Issue 4 279 The Surgical Treatment of the Aditus- Block in Patients with Some Forms of Suppurative Otitis Media Merab Adamia Department of ENT-Diseases, Tbilisi State Medical Academy, Georgia Address for Correspondence : Department of ENT-Diseases, Tbilisi State Medical Academy, 33, Chavchavadze ave.,380079 Tbilisi, Georgia, Tel: +995 32 231230, Fax: + 995 32 294786, E-mail: merabadamia@hotmail.com Abstract Intraoperative findings and histological investigations of the adito-antral region in patients with some forms of suppurative otitis media have shown, that in 76-80% of cases the blockade of the aditus was evident. Taking this fact into account, we should think that the conservative treatment of these patients ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Ethics in Psychiatry Bella Mamulashvili Department of Social Sciences, Tbilisi State Medical University, Georgia Abstract Regarding the principle "do no harm" in psychiatry the issue of applying physicians and medical personnel for hostile purposes is specifically acute. This issue can have number of aspects. From the ethical point of view it is necessary to distinguish between two groups of wrong medical diagnoses. First of them includes wrong diagnoses by the doctors, implying "honest errors" and the second group involves those diagnoses, which not only wrongly describe condition of psychiatric health, but also they are conditioned by non-medical factors, for purposes of politics. This can be said not only about the well known protectors on the human rights ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Psychosocial Importance of Educational Program for Bronchial Asthma Khatuna Jgushia I. Pagava Scientific-Research Institute of Pediatry. Tbilisi, Georgia Abstract Investigation and correction of psychosocial disorders in patients with bronchial asthma, as psychosomatic pathology, is one of the major tasks for successful treatment. In this connection, the individual program was elaborated and investigations of its efficacy were carried out. Obtained data authentically demonstrate that knowledge, acquired during an educational program and practical skills of disease management makes available to reduce stress and emotional limitation, achieve well-being of asthmatic childe, which in turn has the favorable influence on quality of life and social aspects. ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 October/December, Volume 2, Issue 4 351 Hip Joint Function Dynamics in the Process of Physical Rehabilitation in Case of Spine Osteochondrosis Manana Rukhadze Department of Therapeutic Gymnastics, Sports Medicine and Ridetherapy, State Medical Academy of Georgia Abstract Certain syndromes of spinal osteochondrosis are characterized by movement amplitude restriction in hip joint. Goal of the work is development of optimal program for hip joint function recovery in the course of physical rehabilitation of spinal osteochondrosis. 35 patients of both sexes, 34-56 years old were under surveillance. Ridetherapy (therapeutic riding) was used in combination with classical methods of physical rehabilitation (therapeutic gymnastics, massage, physical therapy) and independently. ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Comparative Analysis of Fixed Set and Spatial Imaginations of Practically Healthy Child in Correlation with Academic Progress Nino Khmaladze, Jale Mamporia, George Kavtaradze Scientific-research Institute of Pediatry, Georgia Abstract Have been studied such medical-biologic and psychosocial factors (mother's attitude towards child and family, interpersonal attitudes of child to surrounding individuals, quality of memory, developmental level of spatial imaginations, personal structure and type of fixed set) that affect the quality of study. Total of 217 practically healthy children (healthy group I and group II) aged 7 to 12 years were involved in our research. Owing to factor analysis of carried out research it is obvious, that not separate ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 271 Some Issues on Surgical Correction and Diagnostics of Congenital Malformations of Anus and Rectum in Children Avtandil Kutubidze, Tamaz Gachechiladze Department of Pediatric Surgery, Tbilisi State Medical University Abstract There were 54 patients under study, which have been operated on (protoplast) and suffered from insufficiency of anal aperture, due to congenital malformations of anus and rectum. On the basis of analysis of our own material we came to a conclusion that complications - chronic construction and fecal incontinence have been caused by tactical and technical mistakes of the surgical correction of congenital malformation of anus and rectum. The tactical mistakes (17) were caused by erroneous definition of the height of ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 243 Hypoglycemia Risk Management at the Georgian Diabetic Camp Koba Koplatadze, Manana Koplatadze, Lika Kacharava, David Virsaladze Department of Enocrinology of Tbilisi State Medical University; Georgian Diabetic Camp; Tbilisi; Georgia. Abstract We have studied record sheets of campers (293) during 10 days sessions in the years 1996-2000 of the Georgian diabetic camp. Totally 24 000 blood glucose determination were done. There were 635 episodes of hypoglycemia, during observation period (blood glucose < 70 mg/dl) In 522 cases (82%), campers detected hypoglycemia by themselves. In 67 cases (10,7%) campers had a feeling of high blood glucose and in 18 cases (7,5%) hypoglycemia was recognized by other campers or stuff members. Probability ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 231 Immunotropic, Embryotoxic and Mutagenic Effects of Influenza Virus in Guinea-Pigs and Protective Role of Plaferon Rusudan Khachapuridze, Boris Korsantia Institute of Medical Biotechnology of Academy of Sciences, Tbilisi, Georgia Abstract Acute influenza infection in guinea-pigs was followed by a gradual decrease in the immunological parameters. Plaferon was highly successful in reversing immunosuppression (IFNa,g and the phagocytosis index were notably stimulated). Influenza virus exerted a marked embryotoxic effect in pregnant animals, causing death of the embryo or fetus at various times during pregnancy. An antiembryotoxic effect of plaferon with improvement in indices of preimplantation mortality of fetus was showed (from ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 213 Specificity of Tumor-like Bone Lesion Location in Children Marina Gudushauri, Ramaz Chikhladze Department of Traumatology and Orthopedics, Tbilisi State Medical University Abstract Analyses of the operative materials obtained from the children with diagnosed tumor-like bone lesions in 1981-2000, revealed that during the study period 172 cases of bone cyst, fibrous dysphasia, non osteogenic fibroma (metaphysis fibrous defect) and eosinophilic granuloma were registered. Most often tumor-like bone lesion developed in shinbones, arm and thighbones. Besides, mentioned above lesions were characterized by selective location in all the bones. This fact must be taken into account when the lesion is being diagnosed. Key words: tumor-like bone ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 203 Clinical Application of Ornidazol (Tiberal, Novornid) Among the Patients with Chronic Trychomonal (Mycotic) Urethritis George Galdava, Iosef Shurgaia Andrological Department of S/R Institute of Dermatovenerology, Tbilisi, Georgia Abstract For the last years mycotic infection was widespread, and in the result of this fact the infection turned into the serious problem. Preporations (Methronidazol, Tinidazole and etc.), which were used earlier, have lost their effectivity. Because of their using for a long time the infection acquired the stability. According to the researches it might be affirm that the preparations of Ornidazol have the highest effectivity for the Trichomonat infection treatment. During the treatment it is good to ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 263 Mildronate Effect on Physical Working Capacity Among Highly Qualified Judokas Zurab Kakhabrishvili, Naira Chabashvili, Valeri Akhalkatsi, Tea Skhirtladze, Tamar Chutkerashvili Department of Sport Rehabilitation, Tbilisi State Medical University Abstract The effect of Mildronate on physical working capacity among judokas has been investigated. It is stated, that effect of Mildronate is more efficient in case of aerobic type of physical training and can be used as an additional pharmacological agent for the athletes. Mildronate does not belong to doping. Key words: physical working capacity, highly qualified judokas, left ventricular functional parameters, Mildronate Introduction he main task of contemporary ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 220 Effectiveness of Aciclovir Treatment of Encephalities and Cerebral Dishaemia Caused by Viral Intracranial Infections Ia Rukhadze, Manana Gordeziani, Nino Ninua Neurology Department of Tbilisi State Medical University Abstract The purpose of the study was differential diagnosis and treatment of cerebral dishaemia and encephalitis, caused by intracranial viral infections. Neurovisual methods of investigates were used: CT, MRI and doplerography, IgM and IgG-antibody test in blood and cerebrospinal fluid, blood test for immunoglobulin examination by turbidimetric method and examination of lymphocytes. 39 patients were observed, 17- encephalitis and meningoencephalitis, 22-cerebral circulation disturbances (11-ischemic stroke, 5- ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 107 The Role of Lithium in Pathogenesis of Bronchial Asthma on the Basis of Studying its Effect on Regulation of Neuro-Immuno-Endocrine Systems Eka Rodonaia, Tamaz Churadze Scientific-Research Institute of Pediatrics Abstract The aim of presented work was to consider the role of lithium in pathogenesis of bronchial asthma on the basis of studying its effect on regulation of Neuro-Immuno-Endocrine systems. In order to correct errors in the systems the effective method of treatment has been devised. 80 children aged 1-14 years suffering from bronchial asthma have been investigated. All the patients were homogeneous according to their demographic- anamnetic data and studied parameters. Decrease in concentration of lithium ions was registered ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 139 Reflexotherapeutic Methods Prove Effective in the Treatment of Children with Nocturnal Enuresis Grigor Kakliani, Levan Kakliani, Barnab Nikoladze Tbilisi State Medical University Central Clinical Hospital, Georgia Abstract Nocturnal enuresis represents a serious problem in children and adults. Multi-etiologic nature of the disorder requires versatile methods of treatment. The present study demonstrates a reliable (93,2%)efficacy of the treatment using electro puncture and shiatsu point massage. The abovementioned methods are recommended as important therapeutic means in the treatment of nocturnal enuresis. Keywords: nocturnal enuresis, reflex therapy, electro puncture, point massage Introduction octurnal ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 103 Good Clinical Principles (GCP) Standards in Conduct of Clinical Trials in Georgia Nikoloz Gongadze, Levan Shalamberidze, Zaza Chapichadze Pharmacological Committee, Ministry of Health of Georgia Abstract Background: This article presents the principles for carrying out clinical trials of drugs in Georgia in compliance with the international standards and the Declaration of Helsinki of the World Medical Association and WHO Good Clinical Practice standards. Methods: The review of 7 international multi-center clinical trials in Georgia and the new legislation of Georgia and European guidelines in this field are presented in the article. The ways of adaptation and implementation of this rules in Georgian practice are discussed. Ethical, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 January/March, Volume 2, Issue 1 25 Changes of Labrocytes in Experimental Infection by E.coli and S.aureus Zaza Avaliani Department of Pathological Anatomy, Tbilisi State Medical University Abstract Reactive hyperplasias of lymph nodes do not show specific changes, because it is impossible to recognize etiopathogenesis of the disease. On the basis of molecular biology and molecular pathology it is perspective to detect the morphological, cytochemical, ultrastructural and molecular changes which are specific for different etiopathogenetic factors. The present study there is presents the changes of labrocytes in experimental infection by E. coli and S. aureus. Keywords: labrocytes, experimental infection, E.coli, S.aureus, lymph nodes, reactive hyperplasia ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Tocoferol Acetate during the Treatment of Primary Intrathoracic Pediatric Tuberculosis Nana Tskhakaia, Nina Manjavidze, Natela Okujava Department of Pediatrics, Tbilisi State Medical University; M. Iashvili Children's Central Hospital, Georgia Abstract The patients of 1-14 age with intrathoracic Tuberculosis had treatment by tocoferol-acetate with the DOTS therapy as well, i.e. below 5 years - 50mg per day, for more than 5 years - 100mg per day. The control group included 50 patients. The treatment for them was accomplished by the standard method. The effectiveness of the treatment was defined by intensivity of sygnals that are characteristic for blood's electroparamagnetic centers oxidation process. According to the research, it was clarified, that ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Macroeconomic Indicators of Asthma Maia Rukhadze Department of Allergology and Immunology, Scientific-Research Institute of Experimental and Clinical Medicine, Tbilisi State Medical University, Georgia Abstract A new health care strategy competes with existing ones for quality and limited resources. The health care system and its providers are beginning to turn to health economic analyses to help inform choices in the delivery of care. This review article compares the different health socioeconomic studies and characterizes the economic burden of asthma worldwide. Keywords: bronchial asthma, costs, socioeconomics A sthma is an important cause of chronic morbidity and crucial health problem among children and adults worldwide, ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 Redox-Potential of Liver at Insulin Dependent Experimental Diabetes Mellitus David Delibashvili, Nino Kipiani, Manana Namoradze, Tsisana Kipiani Tbilisi State Medical University, Georgia Introduction D iabetes Mellitus is one of the most important problems in modern Medicine. Its wide spread and the peculiarities of clinics make this disease as not only medical but also social problem. Thus is clearly understandable the huge attention to Diabetes Mellitus pathogenesis research and elaboration of new treatment media. In spite of that there are a lot of unclear points around it. Among them of importance are the cellular metabolic processes. The clinical study of these processes meets the serious problems with receiving ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2003 April/June, Volume 3, Issue 2 The Changes of Paramagnetic Centers of Blood in Critical State Patients Ilia Nakashidze, Nestan Abdushelishvili Tbilisi State Medical University, Georgia Abstract Critical state of any genesis is accompanied with activation of free radical processes in tissues and organs of patient. The aim of the study was investigation of the pathogenesis of critical states on subcellular, molecular level. We've decided to investigate state of adrenoreceprors of blood cells and metabolism of free nitric oxide. In the blood EPR spectrum has been revealed decrease of signal, characteristic for activated form of adrenoreceptors and increase for their inactivated form. During the critical state the content of nitric oxide (NO) in blood increases sharply as well. It can ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 260 The Treatment of Acute Periodontitis Through the Plasmatic Irradiation Tamar Okropiridze, Giorgi Menabde Tbilisi Medical Academy of a Post Graduated Education, Georgia Abstract The work represents the results of 75 stomatological patient monos or complex treatment through the new method of plasmatic irradiation. It is shown, that physiotherapeutic treatment by the plasmatic stream is much more effective then other well known physiotherapeutic procedures. Decreased the time of treatment, medicine. Immune modulation processes in body are stimulated. Is specified that the mechanisms, which are given the positive effect, defined by the accompanied of plasmatic stream radiation, ozone, its photolise products and pathological part of body ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 267 Neuromediatory Regulation of Aggressive Behavior Konstantine Chichinadze I. Beritashvili Institute of Physiology, Tbilisi, Georgia Abstract Study of the concentration of neuromediators - noradrenalin and serotonin - in the mice hypothalamus showed that in determining dominant behaviour a major role is played by a high level of noradrenalin, and of a submissive behaviour - a high level of serotonin. At the same time low aggressive animals (the so-called "transitional" group) were characterized by the correlation of noradrenalin/serotonin, which determined their place between dominant and submissive animals. Keywords: noradrenalin, serotonin, hypothalamus, submissive/ aggressive behaviour tudy of the concentration ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 July/September, Volume 2, Issue 3 247 Medication errors in Health Care Natia Kvizhinadze Department of Social and Clinical Pharmacy, Department of Public Health and Health Management, Tbilisi State Medical University Abstract The purpose of the article is to provide the Georgian population with the tools to avoid the medication errors in everyday life and educated them in using, storage drugs. The main focus of the research is to provide a systematic and structured approach medicine using services of the population including documentation of the pharmacy services, their outcomes and implementation strategies. Keywords: pharmacy, selfconcensious, error, drug, pharmacist, health challenges Introductions ccording to the point of international experts ...

TBILISI STATE MEDICAL UNIVERSITY ANNALS OF BIOMEDICAL RESEARCH AND EDUCATION 2002 April/June, Volume 2, Issue 2 182 Congenital Ichthiosis (Case Report) Irma Manjavidze, Inga Mamuchishvili, Maka Rizvadze, Mzia Ugrechelidze, Karaman Pagava Department of Pediatry, Tbilisi State Medical University chthiosis, known as a skin of aligator, is a diffuse keratosis. For the first time it was described in the manuscriptes of ancient Chine and Egypt, 1-3 thousand year before Christ. Inborn ichtiosis is the congenital anomaly of skin keratosis, developing during IV-V month of prenatal period. Pathogenesis is unknown. In infants the inborn ichthiosis may be revealed in following different forms: vulgar ichthiosis, ichthiosis linked with chromosome, plateform ichthiosis (erythrodermia similar to ichthiosis, nonbullar, ...