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Center for Environmental Health Studies (617) 482-9485 44 Farnsworth Street, Boston, MA 02210 http://www.jsi.com * Findings were statistically significant (strong evidence) + Evidence of a dose-response relationship (strongest evidence) Page 31 Cervical and Uterine Cancer and Exposure to Ionizing Radiation Summary: Moderate evidence has been recorded of a possible connection between cervical and uterine cancers and exposure to ionizing radiation. This evidence is based upon studies of nuclear workers and others exposed to ionizing radiation. The National Research Council’s has not determined whether the uterus is sensitive to ionizing radiation. Cervical and uterine cancers are not designated as “specified” cancers under the Energy Employees Occupational Illness Compensation Program Act. Historically, cervical cancer ...

For Internal Use Only. Not For Use With The Public. This material is intended for insurance informational purposes only and is not personal medical advice for clients. Endometrial ( Uterine ) Cancer Endometrial ( uterine ) cancer is diagnosed in almost 37,400 women/year in the U.S. Although cancer death rates have been declining since the 1930’s due primarily to earlier diagnosis, endometrial cancer still accounts for approximately 6,400 cancer deaths each year. It occurs most frequently in women between the ages of 50 and 70. Risk factors for endometrial cancer include: • higher socioeconomic status • hypertension • obesity • diabetes mellitus • tamoxifen treatment of breast cancer • estrogen replacement therapy (if not combined with progesterone) Women generally present with vaginal bleeding, and the ...

Copyright © 1998 by W.B. Saunders Company. All rights reserved. 510 A BASIC INFORMATION DESCRIPTION Cancer of the endometrium (lining of the uterus). It usually affects postmenopausal women ages 50 to 60. FREQUENT SIGNS AND SYMPTOMS Early stages: • Bleeding or spotting, especially after sexual inter- course. This often occurs after menstrual activity has ceased for 12 months or more. A watery or blood- streaked vaginal discharge may precede bleeding or spotting. • Enlarged uterus. It is sometimes a large enough mass to be felt externally. Later stages: • Spread to other organs, causing abdominal pain, chest pain and weight loss. CAUSES Unknown. Appears to be linked to several predisposing factors listed in Risk. RISK INCREASES WITH • Diabetes mellitus. • Obesity. • High blood pressure. • Use of estrogen without ...

Uterine Corpus Cancer 106 CANCER INCIDENCE AND MORTALITY IN NEW MEXICO, 1970-1996 Major Epidemiologic Features Cancer of the uterine corpus is the fourth most commonly diagnosed cancer in U.S. women, accounting for about 6% of all annual cancer diagnoses. Most uterine cancers occur within the lining of the uterus, the endometrium, and thus the disease frequently is referred to as endometrial cancer . Hormones play a major role in the development of these cancers. Over the past several decades, incidence rates in the U.S. rose sharply to a peak in the mid-1970's, declined by roughly one-third from 1975 to the mid-1980's, and have since remained steady. This rise and subsequent fall in incidence is believed to be the result of widespread use of estrogen replacement therapy in the late 1960's and early 1970's, followed by a dramatic change in such usage in the late 1970's. Mortality ...

uterine cancer Cancer of the Uterine Corpus and Cervix David Toub, M.D. Medical Director Newton Interactive ACS Statistics, 1992: Incidence corpus 32,000 ovary 21,000 cervix 13,500 other 4500 Mortality 4400 13,000 5600 1000 Risk Factors: Cervix HPV, HPV, HPV Smoking Immunosuppression ?low beta-carotene intake Corpus Hyperestrogenism ...

All-Ireland cancer statistics 1994-96 69 Uterine cervix 14. MALIGNANT CANCER OF THE UTERINE CERVIX ICD-O.2 C53 ICD-10 C53 ICD-9 180 Key facts • Average of 259 new cases (105 deaths) per year, 1994-96. • 10th most common site for cancer incidence, and 10th most common cause of cancer deaths, in females. • Median age at diagnosis 46 years, much lower than for cancers as a whole. • Incidence rates about 25% higher in urban compared with other populations. • Incidence rates below average for the EU. Summary statistics Table 14.1 Incidence 1994-96 On average each year, 259 new cases of malignant cervical cancer were diagnosed in Ireland. This was the tenth most common site of malignant cancer in women. On average, Irish women were estimated to have a 1-in-120 chance of developing ...

All-Ireland cancer statistics 1994-96 73 Uterine corpus 15. MALIGNANT CANCER OF THE UTERINE CORPUS ICD-O.2 C54 ICD-10 C54 ICD-9 182 This category includes the main body of the uterus, but excludes the cervix (ICD-10 code C53: Chapter 14) and unspecified parts of the uterus (C55). Key facts • Average of 299 new cases (60 deaths) per year, 1994-96. • 7th most common site for cancer incidence, and 14th most common cause of cancer deaths, in females. • Incidence rates below the EU average. Summary statistics Table 15.1 Incidence 1994-96 On average each year, 299 new cases of malignant cancer of the uterine corpus (body of uterus) were diagnosed in females, in Ireland as a whole. This was the seventh most common cancer site in females and more common than invasive cancer of the ...

51 T he presence of simultaneous carcinomas involving both the ovary and uterine corpus is rel- atively uncommon, and only 0.7–10% of patients with epithelial ovarian or uterine cancers have been found to have simultaneous tumours in large series. 1 However, these synchronous tumours represent a diagnostic and ther- apeutic challenge, particularly if they have a similar histol- ogy. Here we present the case of a 34-year-old woman with endometrioid cancers of both ovaries and adenocarcinoma of the uterus. C A S E R E P O R T The patient was referred to our hospital because of metror- rhagia and lower abdominal pain of six months duration. She had started to menstruate at the age of 14 and her periods were irregular, occurring every 2–3 months, but with no associated abdominal pain. Five years earlier she had a spontaneous abortion during the12 ...

1030 THE NEW ENGLAND JOURNAL OF MEDICINE April 18, 1996 MEDICAL PROGRESS REVIEW ARTICLES CANCER OF THE UTERINE CERVIX S TEPHEN A. C ANNISTRA , M.D., AND J ONATHAN M. N ILOFF , M.D. From the Division of Medical Oncology, Department of Medicine, Dana–Far- ber Cancer Institute (S.A.C.); the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Beth Israel Hospital (J.M.N.); and Harvard Medi- cal School (S.A.C., J.M.N.) — all in Boston. Address reprint requests to Dr. Can- nistra at the Dana–Farber Cancer Institute, 44 Binney St., Boston, MA 02115. 1996, Massachusetts Medical Society. I NVASIVE cervical cancer is uncommon in the Unit- ed States, with an incidence of 15,800 cases and 4800 deaths in 1995. 1 This ...

AbstractID: 6615 Title: Influence of ovoid shields and geometry of insertion on doses to critical structures in Fletcher-Suit intracavitary application For the treatment of uterine cervix cancer , boost dose is delivered using intracavitory brachytherapy. This mode of treatment often involves high dose to the critical structures such as anterior rectal wall and the bladder. The rectal and bladder tolerances are very important while using High Dose Rate (HDR) brachytherapy. In order to reduce dose to these critical structures the Fletcher-Suit applicator used for intracavitary treatments is designed with a shields on ovoids. However, there is no published data in the literature on quantitative reduction of doses to critical organs due to the shields. Plus the effectiveness of these shields if the quality of intracavitory insertion is suboptimal. In view of these uncertainties the dosimetry data in 30 intracavitory ...

UTERINE CANCER OVERVIEW THE FEMALE REPRODUCTIVE SYSTEM DESCRIPTION Uterine cancer (endometrial cancer ) is a malignancy of the uterus , found in women. It affects the lining of the uterus (endometrium). Uterine cancer is most often a type of cancer called an adenocarcinoma . It is the most commonly diagnosed cancer of the female reproductive system . Other names sometimes used for uterine cancer are cancer of the uterus, endometrial cancer , endometrial carcinoma , cancer of the uterine corpus , or cancer of the uterine body. Two other types of cancer that occur in the uterus are different from endometrial cancer . They are cancers of the cervix , which most often affects the surface cells (squamous cells) lining the cervix, and uterine sarcoma, which affects the muscle layer of the uterus (myometrium). Uterine sarcoma ...

Low-cost technology for screening uterine cervical cancer V Aditya Parashari, 1 Veena Singh, 2 Ashok Sehgal, 3 Labani Satyanarayana, 4 Pushpa Sodhani, 4 & Madan M. Gupta 2 We report on an illuminated, low-cost (Rs 1500 (US$ 36)) magnifying device (Magnivisualizer) for detecting precancerous lesions of the uterine cervix. A total of 403 women attending a maternal and child health care clinic who had abnormal vaginal discharge and related symptoms were referred for detailed pelvic examination and visual inspection by means of the device after the application of 5% (v/v) acetic acid. Pap smears were obtained at the same time. The results were compared with those obtained using colposcopy and/or histology. The Magnivisualizer improved the detection rate of early cancerous lesions from 60%, for unaided visual ...

REVIEW ARTICLE CURRENT SCIENCE, VOL. 78, NO. 1, 10 JANUARY 2000 52 Cancer of the uterine cervix and human papillomavirus infection B. C. Das*, V. Gopalkrishna, Suresh Hedau and Sanjay Katiyar Division of Molecular Oncology, Institute of Cytology and Preventive Oncology (ICMR), Maulana Azad Medical College Campus, Bahadur Shah Zafar Marg, New Delhi 110 002, India Human papillomaviruses (HPVs) have emerged as the principal sexually transmitted causal agents in the development of cancer of the uterine cervix in women. They also cause a variety of benign lesions, warts, intraepithelial neoplasia and anogenital, oral and pharyngeal papillomas. Presently, more than 100 HPV genotypes have been identified in humans, and about one-third ...

45 ENDOMETRIAL ( UTERINE CORPUS) CANCER INCIDENCE BY COUNTY, BLACK FEMALES, NEW JERSEY - 1986-1990 AND 1991-1996 1 COUNTY 1986-1990 1991-1996 Number Rate Number Rate 2 2 Atlantic 13 11.4 21 13.4 Bergen 15 14.1 29 18.8 Burlington 11 10.1 28 20.9 Camden 25 13.6 35 14.4 Cumberland 15 30.0 6 8.3 Essex 115 14.7 146 14.6 Gloucester 5 8.9 10 14.0 Hudson 25 15.6 44 20.1 Mercer 21 14.3 28 14.2 Middlesex 8 9.5 24 18.4 Monmouth 21 16.3 27 15.0 Morris --- --- 8 19.1 Ocean --- --- 7 23.3 Passaic 19 14.8 29 15.6 Salem --- --- ...

44 TABLE 21. ENDOMETRIAL ( UTERINE CORPUS) CANCER INCIDENCE BY COUNTY, WHITE FEMALES, NEW JERSEY - 1986-1996 1 COUNTY 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 (Prelim.) No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate No. Rate Atlantic 24 19.9 26 22.6 23 17.4 15 14.2 27 22.9 33 24.5 30 24.2 37 31.2 35 27.9 26 21.4 22 18.0 Bergen 123 20.6 136 24.1 121 20.6 115 20.2 98 16.7 161 29.2 135 23.9 125 22.3 139 24.6 126 22.6 138 23.9 Burlington 26 13.7 41 22.1 31 15.9 40 19.2 42 21.3 38 19.3 35 18.0 59 28.9 57 26.8 57 28.2 47 22.3 Camden ...

71 Cancer of the Uterine Cervix 12 12.1. INTRODUCTION AND SUMMARY The registration and classification of cancer of the cervix is more difficult than that of other cancers, as the majority of cancers of the cervix are very early lesions detected because of screening. Opinions differ on whether these lesions are cancerous or pre-cancerous, and on their likelihood of progressing, without treatment, to invasive cancer . The National Cancer Registry’s policy is to register all cancers of the cervix, including CIN III, regardless of type, if they have been verified by histology. However, the lesions registered as "in situ" below would not be registered as " cancer " by the majority of cancer registries and are not included in international comparisons. Invasive cancers of the cervix make up only a small proportion of female cancers (1.8%) (Table 12.1). Mortality for invasive cancers ...