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Volume 1, Issue 2 Spring 2001 8 Health Watch PACE/Queens College WHPP Health Watch Spring 2001 Vol. 1 Issue 2 Written, Edited and Compiled by: Sylvia Kieding, B.A. Kim Knowlton, MS Amy Manowitz, MPH Steve Markowitz, MD Lyndon Rose, MD, MPH Other Contributing Authors David Fry Mark Griffon This newsletter has been made possible through funding from the Department of Energy, contracts: DEF-FC03-96 SF 21260, DE-FC03-97S F21512, awarded to PACE International Union. In October 2000, the PACE Worker Health Protection Program conducted the first early lung cancer detection screenings on the CT scanner mobile unit and held ribbon-cutting ceremonies at the local union halls of the three gaseous diffusion sites. The kick-off ceremonies were a great success thanks to the local union staff that organized each event. All the events were ...

Cancer Detection Using State Registries in Nationwide Cohort studies such as The Adventist Health Study 2 (AHS-2) Susan Preston-Martin, Ph.D. University of Southern California, Los Angeles, Ca. Gary Fraser, M.D. Loma Linda University, Loma Linda, Ca. Page 2 The Problem • AHS-2 members in all states • Logistics of separate negotiations with 50 state registries (including DC) • State –specific IRB approval • Record Linkage Logistics Page 3 Black Enrollment Goals by region: darker shade equals higher goal 5 4 7 6 8 3 2 1 Page 4 Goal by Region Black Adventists 44,676 Total #subjects Rank Region 3,877 (5) Lake 3,422 (6) S. Western ...

Colorectal Cancer : The Importance of Prevention and Early Detection 2001 “We now have clearer insight into the natural history of colorectal cancer , better understanding of its biologic features, and clinical skills with which to intervene and make a difference for many people. Colorectal cancer screening has come of age.” Sidney J. Winawer, MD, Memorial Sloan-Kettering Cancer Center, New York Reprinted by permission of The New England Journal of Medicine, Massachusetts Medical Society DEPARTMENT OF HEALTH AND HUMAN SERVICES CENTERS FOR DISEASE CONTROL AND PREVENTION Safer • Healthier • People A T A G LANCE CT DC DE MA MD NH NJ RI VT 25.6–38.6% 38.7–43.5% 43.6–46.9% 47.0–56.1% Percentage of Adults Aged 50 Years or Older Who Had Colorectal ...

812 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 49, NO. 8, AUGUST 2002 Confocal Microwave Imaging for Breast Cancer Detection : Localization of Tumors in Three Dimensions Elise C. Fear* , Member, IEEE , Xu Li , Student Member, IEEE , Susan C. Hagness , Member, IEEE , and Maria A. Stuchly , Fellow, IEEE Abstract— The physical basis for breast tumor detection with microwave imaging is the contrast in dielectric properties of normal and malignant breast tissues. Confocal microwave imaging involves illuminating the breast with an ultra-wideband pulse from a number of antenna locations, then synthetically focusing reflections from the breast. The detection of malignant tumors is achieved by the coherent addition of returns from these strongly scattering objects. In this paper, we demonstrate the feasibility of detecting and localizing small ( 1 cm) tumors in ...

130 IEEE MICROWAVE AND WIRELESS COMPONENTS LETTERS, VOL. 11, NO. 3, MARCH 2001 A Confocal Microwave Imaging Algorithm for Breast Cancer Detection Xu Li , Student Member, IEEE, and Susan C. Hagness , Member, IEEE Abstract— We present a computationally efficient and robust image reconstruction algorithm for breast cancer detection using an ultrawideband confocal microwave imaging system. To test the efficacy of this approach, we have developed a two-dimensional (2-D) anatomically realistic MRI-derived FDTD model of the cancerous breast. The image reconstruction algorithm is applied to FDTD-computed backscatter signals, resulting in a microwave image that clearly identifies the presence and location of the malignant lesion. These simulations demonstrate the feasibility of detecting and imaging small breast tumors using this novel approach. Index Terms— ...

July/August 2003, Vol.10, No.4 306 Cancer Control A Systematic Review and Lessons Learned From Early Lung Cancer Detection Trials Using Low-Dose Computed Tomography of the Chest Gerold Bepler, MD, PhD, Dawn Goodridge Carney, MSPH, Benjamin Djulbegovic, MD, PhD, Robert A.Clark, MD, MBA, and Melvyn Tockman, MD, PhD Background : Computed tomography (CT) screening of the chest has shown promise for early detection of lung cancer , but evidence for a reduction in lung cancer mortality by CT screening is not available. Methods: We reviewed 208 articles to synthesize available evidence for efficacy of CT screening in detecting potentially curative stages of lung cancer and for evidence in reducing lung cancer mortality. Other outcomes of interest included detection rate of cancer and of suspicious lesions, histology and stage of cancer at detection , screening-related morbidity, ...

Fox Chase Cancer Center 2002 Scientific Report Predictors of Tobacco Use Among Cancer Patients. Schnoll, in collaboration with Malstrom, a Rothman, § Miller, § James, § Movsas, § Unger, § Goldberg, § Ridge, § Langer § Continued smoking among cancer patients reduces survival duration, increases risk of disease recurrence and a second primary tumor, and diminishes the efficacy of medical treatment. Patients who continue to smoke exhibit a greater number, more severe, and a longer duration of, disease- and treatment- related complications, including: impaired pul- monary function, xerostomia (which increases risk for esophageal injury), mucositis (which interferes with nutritional intake and increases risk for infection), impaired wound ...

Basic Pancreatic Cancer 93 Detection of p16 and K-ras Mutations is Useful in Pancreatic Adenocarcinoma (PA) and Chronic Pancreatitis (CP) Differential Diagnosis R. Talar-Wojnarowska 1 , A. Gasiorowska 1 , B. Smolarz 2 , H. Romanowicz-Makowska 2 , J. Strzelczyk 3 , A. Janiak 3 , E. Malecka-Panas 1 1 Department of Digestive Tract Diseases, Medical University, Lodz, 2 Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother’s Memorial Hospital, Lodz and 3 Department of General Surgery and Transplantology, Medical University, Lodz, Poland The purpose of the study was to compare the prevalence of p16 and K-ras mutation in PA and CP in order to evaluate their usefulness in differential ...

Disease Markers 18 (2002) 153–158 153 IOS Press Foreword Nanotechnology: Emerging Developments and Early Detection of Cancer A Two-Day Workshop sponsored by the National Cancer Institute and the National Institute of Standards and Technology, August 30–31 2001, on the National Institute of Standards and Technology Campus, Gaithersburg, MD, USA Steven J. Zullo a , Sudhir Srivastava b , J. Patrick Looney c and Peter E. Barker d a Chemistry and Life Sciences Division, Advanced Technology Program, National Institute of Standards and Technology, Gaithersburg, MD 20899-4730, USA b Cancer Biomarkers Research Group, Division of Cancer Prevention , National Cancer Institute, 6130 Executive Plaza North, Suite 3142, Bethesda, MD 20892, USA c Program Office, National ...

EARLY DETECTION OF PROSTATE CANCER Adapted from: Prostate cancer early detection : a clinical perspective. Epidemiologic Reviews 23:1 p.173-180, 2001 Page 2 ABSTRACT Prostate cancer is the most commonly diagnosed malignancy and second leading cause of cancer -related death for men in the United States. The introduction and routine use of serum prostate-specific antigen (PSA) testing in men at risk for the disease has led to significant changes in prostate cancer incidence, presentation and treatment. It is believed that these changes will eventually translate into decreased disease-specific morbidity and mortality. The purpose of the current article is to provide a clinical perspective on prostate cancer early detection by addressing the magnitude of the problem and discussing the various screening tests available. In addition, variations on PSA testing ...

March 2003 The McDougall Newsletter www.drmcdougall.com Page 1 In This Issue • A World of Hope and Dreams – Early Detec- tion. The Example – Prostate Cancer (page 1) • Restrict Protein - Save Your Kidneys (page 1) • Project Healthy Begin- nings Sponsors Califor- nia Resolution for Healthier School Lunches (page 7) • Parents and Grandpar- ents, Unite – Act Now To Change the World (page 9) • Featured Recipes (page 12) A World of Hope and Dreams – Early Detection The Example – Prostate Cancer A Very Painful Story What I am about to tell you has generated more hate mail to me than any other sub- ject I have ever talked about. If you are one of those people who would rather live in a world of hopes and dreams, than learn the hard, but sometimes painful, facts, then please ...

1 CENTERS FOR DISEASE CONTROL AND PREVENTION CENTERS FOR DISEASE CONTROL AND PREVENTION A Call to Action: Prevention and Early Detection of Colorectal Cancer (CRC) CENTERS FOR DISEASE CONTROL AND PREVENTION 5 Key Messages ? Screening reduces mortality from CRC ? All persons aged 50 years and older should begin regular screening ? High-risk individuals may need to begin screening earlier ? Colorectal cancer can be prevented ? Several effective screening options are available; not screening is no longer an option CENTERS FOR DISEASE CONTROL AND PREVENTION Burden of Disease ? Second leading cause of cancer death in US ? American Cancer Society estimates in 2000: • 130,200 new cases ...

12 0278-6648/03/$17.00 © 2003 IEEE IEEE POTENTIALS icrowave imaging for medical applica- tions has been of interest for many years. Microwave images are maps of the electrical property distributions in the body. The electrical properties of various tissues may be related to their physiological state. For example, the properties of tissues change with tem- perature. One application of microwave imaging that has been proposed is mon- itoring hyperthermia, which is the application of heat to tissue. In this case, the changing electrical properties indicate the successful deposition of heat in the tissue of interest. Other changes in electrical proper- ties may be caused by disease. There is some evidence of changes in the prop- erties of cancerous tissues when com- pared to normal tissues. Cancer detec- tion with microwave imaging is based ...

Abstract. In the present study, micrometastasis in the rib marrow of 24 patients with esophageal cancer was examined using RT-PCR. RT-PCR was done using primers corresponding to cytokeratin 18 (CK18), squamous cell carcinoma antigen (SCC), and carcinoembryonic antigen (CEA). In 18 cases, CK18 was also detected in the rib marrow. Only one patient exhibited CEA amplification in the rib marrow. No cases demonstrated SCC amplification as a marker of micro- metastasis in the rib marrow. The information from micro- metastasis detected in the rib marrow using RT-PCR is useful in deciding whether or not adjuvant therapy is necessary after surgery. However, combined analysis using plural markers should be required since sensitivity or specificity of each marker may vary. Further follow-up of the patients is necessary to clarify the clinical impact of micrometastasis in rib marrow. Introduction Esophageal ...

RESEARCH COMMUNICATIONS CURRENT SCIENCE, VOL. 84, NO. 4, 25 FEBRUARY 2003 551 *For correspondence. (e-mail: vb.kartha@mahe.manipal.edu) HPLC-LIF for early detection of oral cancer K. Venkatakrishna, V. B. Kartha*, Keerthilatha M. Pai † , C. Murali Krishna, O. Ravikiran † , Jacob Kurian § , Mohan Alexander † and G. Ullas Center for Laser Spectroscopy, † College of Dental Surgery, § Department of Surgical Oncology, Manipal Academy of Higher Education, Manipal 576 119, India At present, the diagnosis of many cancers relies on the subjective interpretation of morphological changes in biopsy samples. This usually provides only late diagnosis. Early detection , which can provide more successful therapy, is expected to be possible by iden- ...

Structural image texture and early detection of breast cancer Shijia Lu and Murk J. Bottema School of Informatics and Engineering Flinders University PO Box 2100, Adelaide SA 5001, Australia and Cooperative Research Centre for Sensor Signal and Information Processing SPRI Building, Mawson Lakes Blvd, Mawson Lakes, SA 4095, Australia lu@infoeng.flinders.edu.au murkb@infoeng.flinders.edu.au Abstract Structural texture measures are used to address three as- pects of early detection of breast cancer in screening mam- mograms: detection of microcalcification, detection and classification of clustered microcalcification as benign or malignant, and the detection of invasive lobular carcinoma. The use of structural texture features replaces the task of ini- tial detection of complex and poorly modelled image struc- tures such as masses or clustered microcalcifications ...

C A N C E R D E T E C T I O N B Y E N D O S C O P I C F R E Q U E N C Y - D O M A I N F L U O R E S C E N C E L I F E T I M E I M A G I N G ( F D - F L I M ) Thesis presented at the Swiss Federal Institute of Technology, Lausanne by Jérôme Mizeret Page 2 Fluorescence lifetime imaging Rhodamin B in Ethanol. Fluorescence lifetime = 2.8 ns. Phase calculation. Rhodamin B in water. Fluorescence lifetime = 1.7 ns. Phase calculation. Page 3 P R I N C I P L E S Intensity of pixels (i,j) of frame 1 to n j i j i i,j = ? f-i,j - ? b-i,j m i,j = A i,j / B i,j a i,j / b i,j Phase Monitor ?2 ?1 Color image Back-scattered image Fluorescence ...

Abstract. The existence of occult metastasis in peripheral blood has been reported in various tumors. However, in gastric cancer (GC), this metastasis has not been well analyzed. In the present study, to identify circulating cancer cells in patients with GC, peripheral blood samples from GC patients were investigated. Total RNA was extracted from 1.5 ml peripheral blood from 55 patients with GC, from 34 non- cancer patients, and from 10 healthy volunteers. Carcinoembryonic antigen (CEA), cytokeratin 19 (CK19), and 20 (CK20) messenger RNA (mRNA) were used as probes to detect GC cells in the blood samples using real-time reverse trans- criptase polymerase chain reaction (RT-PCR). CEA and CK19 mRNA expression were not detected in the 40 healthy volunteers and non- cancer patients, while 2 of the 40 showed CK20 mRNA expression. In 55 patients with GC, CK19 mRNA was not detected and CEA mRNA was detected ...

AMERICAN CANCER SOCIETY RECOMMENDED GUIDELINES FOR CANCER DETECTION Cancer Type Recommended Screenings Age Male Female Frequency Colorectal Stool Blood Test 50+ X X Every year Flexible Sigmoidoscopy* or X X Every 5 years Double-Contrast Barium Enema X X Every 5 years Or Colonoscopy X X Every 10 years * Flexible sigmoidoscopy together with stool blood test is preferred when compared to stool blood test or flexible sigmoidoscopy alone. All positive tests should be followed up with colonoscopy. Breast Breast Self-Exam 20+ X Every month Clinical Breast Exam 20-40 X Every 3 years Clinical Breast Exam 40+ X Every year Mammogram 40+ X Every year Cervix Pap Test 18+ or X Every year until ...

122 IEEE JOURNAL OF QUANTUM ELECTRONICS, VOL. 38, NO. 2, FEBRUARY 2002 Toward the Development of Miniaturized Imaging Systems for Detection of Pre- Cancer Michael R. Descour, Ari H. O. Kärkkäinen, Jeremy D. Rogers, Chen Liang, Ronald S. Weinstein, Juha T. Rantala, Bahattin Kilic, Erdogan Madenci, Rebecca R. Richards-Kortum, Eric V. Anslyn, Russell D. Dupuis, Randy J. Schul, Christi G. Willison, and Chris P. Tigges Invited Paper Abstract— In this paper, we describe the progress toward the development of miniaturized imaging systems with applications in medical imaging, and specifically, detection of pre- cancer . The focus of the article is a miniature, optical-sectioning, fluorescence microscope. The miniature microscope is constructed from lithographically printed optics and assembled using a bulk micro- machined silicon microoptical table. Optical elements have been ...

NEWS RELEASE FOR IMMEDIATE RELEASE Contact: Susan Burke, Account Executive, Ronald Trahan Associates Inc., 508.647.9782, ext. 20 New Technology for Breast Cancer Detection in Young Women Featured at Emerging Medical Technology Conference Premier business development, strategic partnering, and investment meeting for medical technology executives to be held at Sheraton Boston Hotel, Boston, Oct. 24-25, 2002 RAMSEY, N.J., Oct. 22, 2002 – TransScan Medical Ltd. (www.TSCAN.org), developer and manufacturer of Electrical Impedance Scanning (EIS)-based systems for cancer detection , announced today that it will be one of the featured companies at the Medtech Insight conference – ‘Investment in Innovation (In 3 ): A Preview of Early-Stage Medical Technology Companies’ – to be held at the Sheraton Boston Hotel on October 24-25, 2002. ...